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Live longer, healthier: David Sinclair’s book, Lifespan.

Dr. Lisa Broyles
with Jane Rogers

Slow aging and reduce age-related diseases by applying the latest research in anti-aging science.

Or if you only have 3 minutes...

What you'll learn in this podcast....

Lisa Broyles, MD explains the new science of aging and how to apply it outlined in the best selling book, Lifespan by David Sinclair, PhD. We’ve always thought of aging as the inevitable fate for humans and other living things, but scientists are discovering that aging is better understood as a disease that can be treated, slowed and eventually reversed. Dr. Sinclair, a professor of genetics at Harvard Medical School, surveys the new research around aging and shows how we can add years to our lives, years of health and vibrancy. If aging can be slowed, halted, or even reversed, then age-related diseases like Alzheimer’s can be slowed or prevented altogether. 

Aging is complicated, caused by many factors. The old paradigm was that aging was the cumulative result of damage to our DNA, but new research and clinical studies point to certain genes and enzymes that turn on and off the expressions of our DNA. We are learning how to inhibit the “bad genes” and promote the “healthy ones” in ways that will increase our longevity and avoid so many devastating age-related diseases. 

We can encourage these longevity genes in three main ways: 

-lifestyle changes 
-certain supplements

One of the most effective of the lifestyle interventions is intermittent fasting. This turns on the genes that increase healthy DNA and turns off the bad genes that cause cancer. Fasting  can reset your insulin sensitivity while you’re sleeping. This is one of the best ways to improve insulin resistance, pre-diabetes, or diabetes. One of the more popular ways to fast is to wait 14 to 16 hours after dinner before eating anything again. 

Another important factor is regular exercise. High-intensity exercise like interval training  releases your natural endorphins and improves the function of your body at a cellular level. Dr. Sinclair suggests getting either 30 minutes of exercise, 5 days a week, or 1 hour, 3 days a week. Putting your body under this kind of stress sends a signal to your cells to stop replicating so fast in order to conserve your energy, thus prolonging longevity. There are other ways to safely stress your body, like cold therapy, which can have similar effects.

Diet, of course, is an especially potent way to prolong a healthy life. Dr. Sinclair suggests eating lots of vegetables and less animal protein. But, as Dr. Broyles points out, diet really should be an individualized concept. There is not any one diet that fits everybody.  Not everybody needs an autoimmune diet, or a paleo diet or a vegan diet. It really depends on your genetics and your past exposures.

Finally, there are new supplements being developed which can greatly promote the body’s natural longevity genes. The anti-inflammatory drug Resveratrol, derived from the skin of red grapes, decreases cellular aging. So does the diabetic drug Meformin, which is proving to have remarkable anti-aging properties. Dr. Broyles discusses these and other newly discovered supplements like the powerful enzymes NMN, (nicotinamide mononucleotide) and NR, (nicotinamide riboside), both NAD (nicotinamide adenine dinucleotide) boosters, which appear to have dramatic effects in preventing and slowing cellular aging.  In the Links & Resources tab below Dr. Broyles provides a list of NMN, NR and NAD products that have the amount they say they do, don’t have any heavy metals and are actually bioavailable for you.

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"I didn't know before that metformin did have this ability to actually inhibit cancer cell formation, especially cancers of the breast, pancreas, colon, and lung. It improves mitochondrial function. Dr. Sinclair is actually saying, "Hey, we should be prescribing metformin as an anti-aging drug regardless of people's blood sugar."
Dr. Lisa Broyles

About Dr. Lisa Broyles, M.D.

Dr. Lisa Broyles, MD

Dr. Lisa Broyles, MD, is trained in the Bredesen Protocol, a personalized program to prevent and reverse cognitive decline. It is estimated that nearly 50 million currently living Americans will die of Alzheimer’s disease if effective prevention and reversal are not implemented–almost 100 times more than have died of COVID-19. Mainstream medicine would have you believe that it can’t be prevented, is untreatable, and progressive, with most patients not surviving beyond three to eleven years post-diagnosis.

But we are learning that the disease is a pathology of multiple causes that is preventable and even reversible in the early stages through the kind of holistic and individualized approach prescribed by the Bredesen Protocol.

A certified functional medicine doctor with an interest in holistic/integrative medicine, Dr. Broyles is transforming medical care in rural North Carolina. Addressing the underlying causes of disease rather than simply treating symptoms, Dr. Broyles uses a systems-oriented, holistic approach that engages both patient and practitioner in a therapeutic partnership. The result has been a palpable rise in health IQ and wellness in the community she serves.

“People are hungry for this kind of patient/physician collaborative care. They want to take charge of their well-being. They want to feel empowered. Too often, though, the insurance system in America limits choices for physicians and patients alike. Functional medicine represents a fundamental paradigm shift from symptom suppression to an integrative body/mind approach to optimal health,” said Dr. Broyles. 

Hoping to help more people than her limited practice can accommodate, Dr. Broyles is reaching out to her community through the Cutting-Edge Health podcast and other platforms. At the end of each podcast, Dr. Broyles will answer your questions.

Having graduated from the Brody School of Medicine at East Carolina University and completed her three-year residency at the University of Tennessee in Knoxville, Dr. Broyles is currently a family practitioner in Saluda, North Carolina.

For the past several years, she served patients at urgent care and occupational medicine centers in South Carolina and Tennessee. Prior to this, she was medical director for the East Tennessee Spine and Nerve Center in Chattanooga and the Johnson City Tennessee Downtown Clinic. Dr. Broyles graduated from Brody school of medicine at East Carolina University in Greenville North Carolina and obtained her functional medicine certification from Functional Medicine university in Greer South Carolina.

Dr. Lisa Broyles on Cutting Edge Health


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